Larvicidal Activity of Pentagalloyl Glucose and Mangiferin Isolated from the Waste of Mango Kernel Against Culex pipiens L.


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Output type: Journal article

UM6P affiliated Publication?: Yes

Author list: Emam M., Abdel-Haleem D.R., Farag S.M., El-Ansari M.A., Sobeh M.

Publisher: Springer Verlag (Germany)

Publication year: 2021

Journal: Waste and Biomass Valorization (1877-2641)

ISSN: 1877-2641

eISSN: 1877-265X

URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112104102&doi=10.1007%2fs12649-021-01532-9&partnerID=40&md5=13c97e3e971cbbd7b094bc40537acef3

Languages: English (EN-GB)


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Abstract

The deadliest insect, Culex pipiens, plays a critical role in the transmission of multiple diseases to livestock, animals, and humans. In the current work, the waste of Mangifera indica (Mango) seed kernels was extracted with ethyl acetate to profile the gallotannins components. Moreover, the major compounds pentagalloyl glucose (PGG) and mangiferin were isolated and their larvicidal activity against C. pipiens was determined. A total of 20 secondary metabolites were annotated based on high-performance liquid chromatography with photodiode array (PDA) detector and mass spectrometry (MS) detection. PGG and mangiferin were isolated and identified depending on different chromatographic and spectroscopic techniques. The extract exhibited good larvicidal activity against the 3rd larval instar of C. pipiens with LC50 value of 64.02 µg/ml, whereas those of pentagalloyl glucose and mangiferin were 169.38 and 232.15 µg/ml, respectively. The tested extract and the two isolated secondary metabolites exploited significant alterations for the tested enzymes (acetylcholinesterase, carboxylesterase, α-esterases, glutathione S-transferase, and cytochrome P-450 monooxygenase) compared to the untreated larvae with p < 0.01. The GST, carboxylesterase, and α-esterase have the main role in the detoxification of PGG and mangiferin. In conclusion, Mango waste could provide a cheap, available, and important source for tackling an environmental problem as an ecofriendly alternative to the currently used chemical insecticides. Graphic Abstract: The strategy of our study using M. indica kernel against C. pipiens larvae.[Figure not available: see fulltext.] © 2021, The Author(s), under exclusive licence to Springer Nature B.V.


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Last updated on 2021-22-11 at 23:21