Synthesis and Toxicity of Graphene Oxide Nanoparticles: A Literature Review of in Vitro and in Vivo Studies


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Output type: Journal article

UM6P affiliated Publication?: Yes

Author list: Rhazouani A., Gamrani H., El Achaby M., Aziz K., Gebrati L., Uddin M.S., Aziz F.

Publisher: HINDAWI LTDADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON W1T 5HF, ENGLAND

Publication year: 2021

Journal: BIOMED RESEARCH INTERNATIONAL (2314-6133)

Volume number: 2021

ISSN: 2314-6133

eISSN: 2314-6141

URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108552490&doi=10.1155%2f2021%2f5518999&partnerID=40&md5=3206b7c4d0910b302291434d530a672b

Languages: English (EN-GB)


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Abstract

Nanomaterials have been widely used in many fields in the last decades, including electronics, biomedicine, cosmetics, food processing, buildings, and aeronautics. The application of these nanomaterials in the medical field could improve diagnosis, treatment, and prevention techniques. Graphene oxide (GO), an oxidized derivative of graphene, is currently used in biotechnology and medicine for cancer treatment, drug delivery, and cellular imaging. Also, GO is characterized by various physicochemical properties, including nanoscale size, high surface area, and electrical charge. However, the toxic effect of GO on living cells and organs is a limiting factor that limits its use in the medical field. Recently, numerous studies have evaluated the biocompatibility and toxicity of GO in vivo and in vitro. In general, the severity of this nanomaterial's toxic effects varies according to the administration route, the dose to be administered, the method of GO synthesis, and its physicochemical properties. This review brings together studies on the method of synthesis and structure of GO, characterization techniques, and physicochemical properties. Also, we rely on the toxicity of GO in cellular models and biological systems. Moreover, we mention the general mechanism of its toxicity. © 2021 Asmaa Rhazouani et al.


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Last updated on 2021-22-10 at 23:20